2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
    Neuronal Signaling
  4. Calcium Channel

Calcium Channel

Ca2+ channels; Ca channels

Calcium Channel

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Calcium channel is an ion channel which displays selective permeability to calcium ions. It is sometimes synonymous as voltage-dependent calcium channel, although there are also ligand-gated calcium channels. Voltage-gated calcium (CaV) channels catalyse rapid, highly selective influx of Ca2+ into cells despite a 70-fold higher extracellular concentration of Na+. Some calcium channel blockers have the added benefit of slowing your heart rate, which can further reduce blood pressure, relieve chest pain (angina) and control an irregular heartbeat.

Calcium Channel Isoform Specific Products:

Calcium Channel Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-121186R
    Bevantolol hydrochloride (Standard)
    		Antagonist
    Bevantolol (hydrochloride) (Standard) is the analytical standard of Bevantolol (hydrochloride). This product is intended for research and analytical applications. Bevantolol hydrochloride is a selective β1 and α1-adrenergic receptor antagonist with pKi values of 7.83, 6.9 in rat cerebral cortex, respectively. Bevantolol hydrochloride is a potent Ca2+ antagonist.
    Bevantolol hydrochloride (Standard)
  • HY-B0280R
    Ranolazine (Standard)
    		Inhibitor
    Ranolazine (Standard) is the analytical standard of Ranolazine. This product is intended for research and analytical applications. Ranolazine (CVT 303) is an anti-angina drug that achieves its effects by inhibiting the late phase of inward sodium current (INa and IKr with IC50 values of 6 μM and 12 μM, respectively) without affecting heart rate or blood pressure (BP). Ranolazine is also a partial fatty acid oxidation (FAO) inhibitor. Antianginal agent.
    Ranolazine (Standard)
  • HY-120411
    Sadopine
    		Modulator
    Sadopine is an allosteric modulator for dihydropyridine receptor ((-)Sadopine as positive allosteric modulator and (+)Sadopine as negative allosteric modulator). Sadopine interacts with dihydropyridine (DHP)-sensitive L-type calcium channels.
    Sadopine
  • HY-117055
    Ro 18-3981
    		Inhibitor
    Ro 18-3981 is a dihydropyridine that inhibits cardiac Ca2+ channels. Ro 18-3981 shows higher inhibitory activity when the cell membrane is in a depolarized state (Vh=-20 mV: IC50=2.3 nM; Vh=-50 mV: IC50=100 nM).
    Ro 18-3981
  • HY-130358
    PDDHV
    		Activator
    PDDHV is a calcium absorption inducer and may achieve 45Ca2+ influx by stimulating vanillic acid receptor VR1. PDDHV induces 45Ca2+ uptake (EC50: 70 nM) in rat dorsal root ganglion neurons (expressing native vanilloid receptors) and calcium mobilization (EC50: 125 nM) in VR1-transfected CHO cells. PDDHV also inhibits [3H]-resiniferatoxin (RTX) binding to the dorsal root ganglion membrane in rats.
    PDDHV
  • HY-17402S2
    Nisoldipine-d7
    		Inhibitor
    Nisoldipine-d7 (BAY-k 5552-d7) is the deuterium labeled Nisoldipine. Nisoldipine(BAY-k 5552) is a calcium channel blocker belonging to the dihydropyridines class, specific for L-type Cav1.2 with IC50 of 10 nM[1][2].
    Nisoldipine-d<sub>7</sub>
  • HY-135110A
    Rp-8-Br-cGMPS
    		Activator
    Rp-8-Br-cGMPS (Rp-8-bromo-Cyclic GMPS) sodium salt is a potent Ca2+-ATPase activator. Rp-8-Br-cGMPS is also an agonist of the rod CNG channel and an inhibitor of PKG. Rp-8-Br-cGMPS sodium salt mediates cytosolic Ca2+ reduction by activating Ca2+-ATPase and subsequently removing Ca2+ from the cell.
    Rp-8-Br-cGMPS
  • HY-106415
    Terflavoxate
    		Antagonist
    Terflavoxate is a flavone derivative with spasmolytic properties. Terflavoxate has Ca2+-antagonistic effect is mainly responsible for Terflavoxate smooth muscle relaxant properties. Terflavoxate has the potential for overactive detrusor research.
    Terflavoxate
  • HY-101621
    Teludipine hydrochloride
    		Inhibitor
    Teludipine is a lipophilic calcium channel blocker.
    Teludipine hydrochloride
  • HY-101674
    Tiapamil hydrochloride
    		Antagonist
    Tiapamil hydrochloride is a calcium channel blocker.
    Tiapamil hydrochloride
  • HY-101616
    ABT-639 hydrochloride
    		Inhibitor
    ABT-639 hydrochloride is a novel, peripherally acting, selective T-type Ca2+ channel blocker.
    ABT-639 hydrochloride
  • HY-101727
    Nexopamil racemate
    Nexopamil racemate is the racemate of Nexopamil. Nexopamil is a combined Ca2+/5-HT2 antagonist on thrombus formation in vivo and on platelet aggregation in vitro.
    Nexopamil racemate
  • HY-101685
    Iganidipine
    		Antagonist
    Iganidipine is a Ca2+ antagonist.
    Iganidipine
  • HY-19062
    SM-6586
    		Antagonist
    SM-6586 is a calcium channel antagonist and inhibitor of Na+/H+ and Na+/Ca2+ exchange transport, potentially for the treatment of cerebrovasular diseases and hypertension.
    SM-6586
  • HY-101669
    TDN345
    		Antagonist
    TDN345 is a Ca2+ antagonist, used for the treatment of vascular and senile dementia including Alzheimer's disease.
    TDN345
  • HY-101621S
    Teludipine-d6
    		Inhibitor
    Teludipine-d6 is the deuterium labeled Teludipine hydrochloride. Teludipine is a lipophilic calcium channel blocker[1][2].
    Teludipine-d<sub>6</sub>
  • HY-B0122S
    Topiramate-13C6
    		Inhibitor
    Topiramate-13C6 (McN 4853-13C6) is the 13C labeled isotope of Topiramate (HY-B0122). Topiramate (McN 4853) is a broad-spectrum antiepileptic agent. Topiramate is a GluR5 receptor antagonist. Topiramate produces its antiepileptic effects through enhancement of GABAergic activity, inhibition of kainate/AMPA receptors, inhibition of voltage-sensitive sodium and calcium channels, increases in potassium conductance, and inhibition of carbonic anhydrase.
    Topiramate-<sup>13</sup>C<sub>6</sub>
  • HY-12650R
    Mirogabalin (Standard)
    		Inhibitor
    Mirogabalin (Standard) is the analytical standard of Mirogabalin. This product is intended for research and analytical applications. Mirogabalin (DS-5565) is a novel, preferentially selective α2δ-1 ligand characterized by high potency and selectivity to the α2δ-1 subunit of voltage-sensitive calcium channel complexes in the CNS.
    Mirogabalin (Standard)
  • HY-136482
    Nemadipine B
    		Inhibitor
    Nemadipine B is a calcium channel blocker and an EGL-19 antagonist. Nemadipine B induces Egl, Vab and Gro phenotypes in Caenorhabditis elegans.
    Nemadipine B
  • HY-111613R
    Pinaverium bromide (Standard)
    		Inhibitor
    Pinaverium bromide (Standard) is the analytical standard of Pinaverium bromide. This product is intended for research and analytical applications. Pinaverium bromide is an L-type calcium channel blocker with selectivity for the gastrointestinal tract, effectively relieves pain, diarrhea and intestinal discomfort, provides good therapeutic efficacies without significant adverse effects on Irritable bowel syndrome (IBS) patients.
    Pinaverium bromide (Standard)
Cat. No. Product Name / Synonyms Application Reactivity
Calcium Channel Isoform Comparison

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